O uso de antibióticos intratecal para meningite bacteriana: quais evidências temos?

Autores

DOI:

https://doi.org/10.37085/jmmv4.n2.2022.pp.1-5

Palavras-chave:

Meningite bacteriana, Antibióticos intratecais, bactérias resistentes a medicamentos, Infecção do sistema nervoso central, Falha terapêutica

Resumo

O tratamento da meningite é uma questão complexa quando se trata de bactérias multiresistente a antibióticos (ATB) limitando as opções de medicamentos que podem atravessar a barreira hematoencefálica e atingir efetivamente o espaço subaracnóide. O impacto na eficácia do arsenal terapêutico disponível, devido ao uso indiscriminado de antibacterianos em escala global, aumenta as chances de falha terapêutica do tratamento empírico inicial e a persistência da falha, apesar da cultura direcionar o tratamento aos patógenos, sem obter resultados satisfatórios. Assim, a utilização de estratégias para otimizar a entrega de antibacterianos ao local da patologia envolve o uso do mecanismo farmacocinético, a fim de alcançar o efeito desejado por meio da administração intratecal. Durante esta revisão, objetivamos avaliar o uso da antibioticoterapia intratecal em pacientes infectados por bactérias multirresistentes e analisar os possíveis efeitos adversos.

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Referências

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Publicado

2022-12-31

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Dias, M. E. M. P., Oliveira, A. C. M. de, Pinheiro Filho, A. A., Nunes, L. P., Rafael, M. V. A., Deocleciano, I. de S. R., Santos Filho, C. B. dos, Ramos, J. G. S., Bem Junior, L. S., & Azevedo Filho, H. R. C. de. (2022). O uso de antibióticos intratecal para meningite bacteriana: quais evidências temos?. Jornal Memorial Da Medicina, 4(2), 1–5. https://doi.org/10.37085/jmmv4.n2.2022.pp.1-5

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