Possível relação das alterações dietéticas de micronutrientes com a sintomatologia comportamental no distúrbio do espectro autista

Autores

  • Nathália de Freitas Penaforte
  • Carlos Augusto Carvalho de Vasconcelos
  • Angélica de Kassia Barbosa Flôr

DOI:

https://doi.org/10.37085/jmmv1.n2.2019.pp.37-45

Palavras-chave:

Autismo, Minerais, Vitaminas, Comportamento

Resumo

Este trabalho teve como objetivo analisar a possível relação das alterações dietéticas de micronutrientes com a sintomatologia comportamental característica do Distúrbio do Espectro Autista (DEA), verificando que complicações podem estar envolvidas e o que isso pode impactar nesse público. Foi realizada uma revisão bibliográfica nas bases de dados eletrônicas “Pubmed”, “Science Direct” e “Scielo”, publicados em inglês e português no período de janeiro de 2002 a outubro de 2019. Utilizou os seguintes descritores de busca: “autistic desorder” AND “vitamins” AND “minerals” AND “gastrointestinal tract” AND “nutrition” AND “behavior” e suas combinações. Na busca, foram encontrados 2.857 artigos, dentre os quais, mediante os critérios de inclusão e de exclusão apenas 47 artigos foram selecionados, e mais 2 livros. Observou-se que esse público tem uma maior probabilidade de ter uma inadequação de micronutrientes, em que pode ser heterogêneo, variando de deficiência a toxicidade, ocasionada pela dieta restritiva e monótona, refletindo assim no seu estado nutricional. A frequência de sintomas intestinais também pode estar atrelada ao agravamento do comportamento alimentar e da sintomatologia típica do transtorno, que consequentemente reflete de forma negativa na absorção desses nutrientes, os quais desempenham papéis cruciais no neurodesenvolvimento. Concluímos que é necessário a realização de novas pesquisas nesta área para avaliar a ingestão alimentar de micronutrientes específicos, para verificar se há comprometimento da absorção desses nutrientes, seu impacto no comportamento característico e na eficácia da suplementação validada neste público. Assim, possibilitando a criação de medidas preventivas, embora as causas do DEA ainda sejam incertas, a influência dos micronutrientes não deve ser negligenciada.

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Biografia do Autor

Nathália de Freitas Penaforte

Discente da Faculdade de Comunicação, Tecnologia e Turismo de Olinda, Olinda, PE, Brasil.

Carlos Augusto Carvalho de Vasconcelos

Docente do Departamento de Nutrição do Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, PE, Brasil.

Angélica de Kassia Barbosa Flôr

Docente do Departamento de Nutrição da Faculdade de Comunicação, Tecnologia e Turismo de Olinda, Olinda, PE, Brasil.

Referências

Lombardi VC, Meirleir KLD, Subramanian K, Nourani SM, Dagda RK, Delaney SL, et al. Nutritional Modulation of the Intestinal Microbiota; Future Opportunities for the Prevention and Treatment of Neuroimmune and Neuroinflammatory Disease. The Journal of nutritional biochemistry, 2018. disorders (ASDs). Microbiome, 2018, 6.1: 133.

Siqueira CC, Ferreira EO, Bittencourt RG, Cavalheiro FR, de Abreu Silveira JA, Santos MFR. O cérebro autista: a biologia da mente e sua implicação no comprometimento social. Revista Transformar, 2016, 8(8), 221-237.

Meguid N, Anwar M, Zaki S, Kandeel W, Ahmed N, Tewfik I. Dietary patterns of children with autism spectrum disorder: a study based in Egypt. Open access Macedonian journal of medical sciences, 2015, 3(2), 262.

Ames, B. N., Elson-Schwab, I., & Silver, E. A. (2002). High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K m): relevance to genetic disease and polymorphisms. The American journal of clinical nutrition, 75(4), 616-658.

Rapin, I., & Goldman, S. (2008). A escala CARS brasileira: uma ferramenta de triagem padronizada para o autismo. Jornal de Pediatria, 84(6), 473-475.

Buie T, Campbell DB, Fuchs GJ, Furuta GT, Levy J, Vandewater J, et al. Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report. Pediatrics 125 (Suppl 1), 2010, S1– S18.

Silva NID. Relação entre hábito alimentar e síndrome do espectro autista. Doctoral dissertation, Universidade de São Paulo, 2011.

Zuchetto AT, Cavalcante TM, Pimenta RA, Zanon PA, Nasser JP. Avaliação da composição corporal de crianças e jovens com deficiência. Revista Portuguesa de Ciências do Desporto, 2014.

Reichow B. Overview of meta-analyses on early intensive behavioral intervention for young children with autism spectrum disorders. Journal of autism and developmental disorders, 2012, 42(4), 512-520.

Caetano MV, Gurgel DC. Perfil nutricional de crianças portadoras do transtorno do espectro autista. Revista Brasileira em Promoção da Saúde, 2018, 31(1).

Cozzolino SMF. Biodisponibilidade de nutrientes. São Paulo: Manole; 2005.

Rose DR, Yang H, Serena G, Sturgeon C, Ma B, Careaga M, et al. Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms. Brain, behavior, and immunity, 2018, 70, 354-368.

Frye RE, Rose S, Slattery J, MacFabe DF. Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome. Microbial ecology in health and disease, 2015, 26(1), 27458.

Nikolov RN, Bearss KE, Lettinga J, Erickson C, Rodowski M, Aman MG, et al. Gastrointestinal symptoms in a sample of children with pervasive developmental disorders. Journal of autism and developmental disorders, 2009, 39(3), 405-413.

Mazurek MO, Vasa RA, Kalb LG, Kanne SM, Rosenberg D, Keefer A, et al. Anxiety, sensory over-responsivity, and gastrointestinal problems in children with autism spectrum disorders. Journal of Abnormal Child Psychology, 2013, 41, 165-176.

Marcelino C. Autismo: a esperança pela nutrição. Rio e Janeiro, Mbooks; 2010.

Adams JB, Johansen LJ, Powell LD, Quig D, Rubin RA. Gastrointestinal flora and gastrointestinal status in children with autism–comparisons to typical children and correlation with autism severity. BMC gastroenterology, 2011, 11.1: 22.

Herndon AC, DiGuiseppi C, Johnson SL, Leiferman J, Reynolds A. Does nutritional intake differ between children with autism spectrum disorders and children with typical development?. Journal of autism and developmental disorders, 2009, 39(2), 212.

Bjørklund G, Waly MI, Al-Farsi Y, Saad K, Dadar M, Rahman MM, et al. The Role of Vitamins in Autism Spectrum Disorder: What Do We Know?. Journal of Molecular Neuroscience, 2019, 1-15.

Guo M, Li L, Zhang Q, Chen L, Dai Y, Liu L, et al. Vitamin and mineral status of children with autism spectrum disorder in Hainan Province of China: associations with symptoms. Nutritional neuroscience, 2018, 1-8.

James SJ, Cutler P, Melnyk S, Jerniga S, Janak L, Gaylor DW, Neubrander JA. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. The American journal of clinical nutrition, 2004, 80(6), 1611-1617.

McGinnis WR. Oxidative stress in autism. Alternative Therapies in Health and Medicine, 2004,10(6), 22-36.

Chauhan A, Chauhan V (2006). Oxidative stress in autism. Pathophysiology, 13(3), 171-181.

Rossignol DA, Frye RE. Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism. Frontiers in physiology, 2014, 5, 150.

Herbert MR. Large brains in autism: the challenge of pervasive abnormality. The Neuroscientist, 2005, 11(5), 417-440.

Pardo CA, Vargas DL, Zimmerman AW. Immunity, neuroglia and neuroinflammation in autism. International review of psychiatry, 2005, 17(6), 485-495.

Fiorentino M, Sapone A, Senger S, Camhi SS, Kadzielski SM, Buie TM, Fasano A. Blood–brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders. Molecular autism, 2016, 7(1), 49.

Yasuda H, Yoshida K, Yasuda Y, Tsutsui T. Infantile zinc deficiency: association with autism spectrum disorders. Scientific reports, 2011, 1, 129.

Crăciun EC, Bjørklund G, Tinkov AA, Urbina MA, Skalny AV, Rad F, Dronca E. Evaluation of whole blood zinc and copper levels in children with autism spectrum disorder. Metabolic brain disease, 2016, 31(4), 887-890.

Dumcke TS (2018). Associação entre exposição a resíduos e dificuldades emocionais e comportamentais de escolares.

Liu X, Liu J, Xiong X, Yang T, Hou N, Liang X, et al. Correlation between nutrition and symptoms: nutritional survey of children with autism spectrum disorder in Chongqing, China. Nutrients, 2016, 8(5), 294.

Lai X, Wu X, Hou N, Liu S, Li Q, Yang T, et al. Vitamin A deficiency induces autistic-like behaviors in rats by regulating the RARbeta-CD38-oxytocin axis in the hypothalamus. Mol Nutr Food Res 2018;62(5). doi:10.1002/mnfr.201700754.

Xu X, Li C, Gao X, Xia K, Guo H, Li Y, et al. Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders. Cell Res. 2018;28:48–68.

Sun C, Xia W, Zhao Y, Li N, Zhao D, Wu L. Nutritional status survey of children with autism and typically developing children aged 4–6 years in Heilongjiang Province, China. Journal of nutritional science, 2013, 2.

Marí-Bauset S, Llopis-González A, Zazpe-García I, Marí-Sanchis A, Morales-Suárez-Varela M. Nutritional status of children with autism spectrum disorders (ASDs): a case–control study. Journal of autism and developmental disorders, 2015, 45(1), 203-212.

Marí-Bauset S, Llopis-González A, Zazpe I, Marí-Sanchis A, Morales Suárez-Varela M. Comparison of nutritional status between children with autism spectrum disorder and typically developing children in the Mediterranean Region (Valencia, Spain). Autism, 2017, 21(3), 310-322.

Esteban-Figuerola P, Canals J, Fernández-Cao JC, Arija Val V. Differences in food consumption and nutritional intake between children with autism spectrum disorders and typically developing children: A meta-analysis. Autism, 2018, 1362361318794179.

Palmieri L, Papaleo V, Porcelli V, Scarcia P, Gaita L, Sacco R, Militerni R. Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1. Molecular psychiatry, 2010, 15(1),

Goh S, Dong Z, Zhang Y, DiMauro S, Peterson BS. Mitochondrial dysfunction as a neurobiological subtype of autism spectrum disorder: evidence from brain imaging. JAMA psychiatry, 2014, 71(6), 665-671.

Al-Farsi YM, Waly MI, Deth RC, Al-Sharbati MM, Al-Shafaee M, Al-Farsi O, Al-Adawi S. Low folate and vitamin B12 nourishment is common in Omani children with newly diagnosed autism. Nutrition, 2013, 29(3), 537-541.

Main PA, Angley MT, Thomas P, O'Doherty CE, Fenech M. Folate and methionine metabolism in autism: a systematic review. Am J Clin Nutr. 2010; 91(6):1598-620.

Bours PH, Wielders JP, Vermeijden JR, van de Wiel A. Seasonal variation of serum 25-hydroxyvitamin D levels in adult patients with inflammatory bowel disease. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2011; 22(11):2857-67.

De Luca, GC Kimball SM, Kolasinski J, Ramagopalan SV, Ebers GC Review: the role of vitamin D in nervous system health and disease. Neuropathol Appl Neurobiol 2013 Aug;(39):458-484

Tostes MH, Polonini HC, Gattaz WF, Raposo NR, Baptista EB. Low serum levels of 25-hydroxyvitamin D(25-OHD) in children with autism. Trends in Psychiatric and Psychoterapy 2012 Sep (34) 3:161-3.

Gong ZL, Luo CM, Wang L, Shen L, Wei F, Tong RJ, Liu Y. Serum 25-hydroxyvitamin D levels in Chinese children with autism spectrum disorders.NeuroReport 2014 Jan 8.25(1):23-7.

KocovskA E, Andorsdóttir G, Weihe P, at al. Vitamin d in the general population of young adults with autism in the faroe islands.J.Autism Dev. Disord 2014 Dec 44(12): 2996-3005.

Adams JB, Audhya T, McDonough-Means S, Rubin RA, Quig D, Geis E, et al. Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity. Nutrition & metabolism. 2011; 8(1):34.

Adams JB, Audhya T, McDonough-Means S, Rubin RA, Quig D, Geis E, et al. Effect of a vitamin/mineral supplement on children and adults with autism. BMC pediatrics. 2011; 11:111.

Mehl-Madrona L, Leung B, Kennedy C, Paul S, Kaplan BJ. Micronutrients versus standard medication management in autism: a naturalistic case-control study. Journal of child and adolescent psychopharmacology. 2010; 20(2):95-103.

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Publicado

21/12/2020

Como Citar

de Freitas Penaforte, N. ., Augusto Carvalho de Vasconcelos, C. ., & de Kassia Barbosa Flôr, A. . (2020). Possível relação das alterações dietéticas de micronutrientes com a sintomatologia comportamental no distúrbio do espectro autista. Jornal Memorial Da Medicina, 1(2), 37–45. https://doi.org/10.37085/jmmv1.n2.2019.pp.37-45

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