The use of intrathecal antibiotics for bacterial meningitis: what evidence do we have?
DOI:
https://doi.org/10.37085/jmmv4.n2.2022.pp.1-5Keywords:
Bacterial meningitis, Intrathecal antibiotics, Drug resistant bacteria, Central Nervous System Infections, Therapeutic FailureAbstract
The treatment of meningitis is a complex issue when it comes to multi-resistant antibiotic (ATB) bacteria, limiting the drug options that can cross the blood-brain barrier and effectively reach the subarachnoid space. The impact on the effectiveness of the therapeutic arsenal available, due to the indiscriminate use of antibacterial on a global scale, increases the chances of therapeutic failure of the initial empirical treatment and a persistence of failure despite the culture of targeting the treatment at the pathogens, while not obtaining satisfactory results. Thus, the use of strategies to optimize the delivery of antibacterials to the pathology site involves using the pharmacokinetic mechanism in order to achieve the desired effect through intrathecal administration. During this review, we aimed to evaluate the use of intrathecal antibiotic therapy in patients infected with multidrug-resistant bacteria
and analyze possible adverse effects.
Downloads
References
GIOVANE, R.A. et al. Central Nervous System Infections. Primary Care: Clinics in Office Practice , [S. l.], v. 45, n. 3, p. 505-518, 9 jul. 2018. DOI 10.1016/j.pop.2018.05.007. Available at: https://pubmed.ncbi.nlm.nih.gov/30115337/. Accessed on: 16 Apr. 2021.
NAU, R. et al. Bacterial meningitis: an update of new treatment options. Expert Review of Anti-infective Therapy, [S. l.], v. 13, n. 11, p. 1401-1423, 18 aug. 2015. DOI 10.1586/14787210.2015.1077700. Available at: https://pubmed.ncbi.nlm.nih.gov/26293166/. Accessed on: 16 Apr. 2021.
VAN DE BEEK, Diederik et al. Nosocomial bacterial meningitis. The New England Journal of Medicine, [S. l.], v. 362, p. 146-154, 14 jan. 2010. DOI 10.1056/NEJMra0804573. Available at: https://pubmed.ncbi.nlm.nih.gov/20071704/. Accessed on: 16 Apr. 2021.
MINISTÉRIO DA SAÚDE. Guia de Vigilância Epidemiológica. 6. ed. aum. Brasília: [s. n.], 2005. 816 p. ISBN 85-334-1047-6.
VAN DE BEEK, Diederik et al. Community-acquired bacterial meningitis. Nature Reviews Disease Primers, [s. l.], v. 2, n. 16074, 3 nov. 2016. DOI 10.1038/nrdp.2016.74. Available at: https://www.nature.com/articles/nrdp201674. Accessed on: 13 Sep. 2021.
ZIAI, Wendy C et al. Improving the role of intraventricular antimicrobial agents in the management of meningitis. Current Opinion in Neurology, [s. l.], v. 22, ed. 3, p. 277- 82, June 2009. DOI 10.1097/wco.0b013e32832c1396. Available at: https://pubmed.ncbi.nlm.nih.gov/19434796/. Accessed on: 13 Sep. 2021.
LEWIN 3rd, John J et al. Current Practices of Intraventricular Antibiotic Therapy in the Treatment of Meningitis and Ventriculitis: Results from a Multicenter Retrospective Cohort Study. Neurocrit Care, [s. l.], v. 30, ed. 3, p. 609-616., June 2019. DOI 10.1007/s12028-018-0647-0. Available at: https://pubmed.ncbi.nlm.nih.gov/30446934/. Accessed on: 13 Sep. 2021.
INAMASU, Joji; ISHIKAWA, Kiyohito; OHEDA, Motoki; et al. Intrathecal administration of colistin for meningitis due to New Delhi metallo-β-lactamase 1(NDM-1)-producing Klebsiella pneumoniae. Journal of Infection and Chemotherapy, v. 22, n. 3, p. 184–186, 2016. Available at:
<https://pubmed.ncbi.nlm.nih.gov/26683242/>. Accessed on: 6 Aug. 2021.
EMIROGLU, Melike; ALKAN, Gulsum ; TURK DAGI, Hatice. Tigecycline Therapy in an Infant for Ventriculoperitoneal Shunt Meningitis. Pediatrics, v. 139, n. 1, p. e20160963, 2016. Available at: <https://pubmed.ncbi.nlm.nih.gov/27974589/>. Accessed on: 6 Aug. 2021.
LI, Xingang; SUN, Shusen; WANG, Qiang; et al. Population Pharmacokinetics of Combined Intravenous and Local Intrathecal Administration of Meropenem in Aneurysm Patients with Suspected Intracranial Infections After Craniotomy. European Journal of Drug Metabolism and Pharmacokinetics, v. 43, n. 1, p. 45– 53, 2017. Available at: <https://pubmed.ncbi.nlm.nih.gov/28616823/>. Accessed on: 6 Aug. 2021
GIOVANE, R.A. et al. Central Nervous System Infections. Primary Care: Clinics in Office Practice , [S. l.], v. 45, n. 3, p. 505-518, 9 jul. 2018. DOI 10.1016/j.pop.2018.05.007. Available at: https://pubmed.ncbi.nlm.nih.gov/30115337/. Accessed on: 16 Apr. 2021.
NAU, R. et al. Bacterial meningitis: an update of new treatment options. Expert Review of Anti-infective Therapy, [S. l.], v. 13, n. 11, p. 1401-1423, 18 aug. 2015. DOI 10.1586/14787210.2015.1077700. Available at: https://pubmed.ncbi.nlm.nih.gov/26293166/. Accessed on: 16 Apr. 2021.
VAN DE BEEK, Diederik et al. Nosocomial bacterial meningitis. The New England Journal of Medicine, [S. l.], v. 362, p. 146-154, 14 jan. 2010. DOI 10.1056/NEJMra0804573. Available at: https://pubmed.ncbi.nlm.nih.gov/20071704/. Accessed on: 16 Apr. 2021.
MINISTÉRIO DA SAÚDE. Guia de Vigilância Epidemiológica. 6. ed. aum. Brasília: [s. n.], 2005. 816 p. ISBN 85-334-1047-6.
VAN DE BEEK, Diederik et al. Community-acquired bacterial meningitis. Nature Reviews Disease Primers, [s. l.], v. 2, n. 16074, 3 nov. 2016. DOI 10.1038/nrdp.2016.74. Available at: https://www.nature.com/articles/nrdp201674. Accessed on: 13 Sep. 2021.
ZIAI, Wendy C et al. Improving the role of intraventricular antimicrobial agents in the management of meningitis. Current Opinion in Neurology, [s. l.], v. 22, ed. 3, p. 277- 82, June 2009. DOI 10.1097/wco.0b013e32832c1396. Available at: https://pubmed.ncbi.nlm.nih.gov/19434796/. Accessed on: 13 Sep. 2021.
LEWIN 3rd, John J et al. Current Practices of Intraventricular Antibiotic Therapy in the Treatment of Meningitis and Ventriculitis: Results from a Multicenter Retrospective Cohort Study. Neurocrit Care, [s. l.], v. 30, ed. 3, p. 609-616., June 2019. DOI 10.1007/s12028-018-0647-0. Available at: https://pubmed.ncbi.nlm.nih.gov/30446934/. Accessed on: 13 Sep. 2021.
INAMASU, Joji; ISHIKAWA, Kiyohito; OHEDA, Motoki; et al. Intrathecal administration of colistin for meningitis due to New Delhi metallo-β-lactamase 1(NDM-1)-producing Klebsiella pneumoniae. Journal of Infection and Chemotherapy, v. 22, n. 3, p. 184–186, 2016. Available at:
<https://pubmed.ncbi.nlm.nih.gov/26683242/>. Accessed on: 6 Aug. 2021.
EMIROGLU, Melike; ALKAN, Gulsum ; TURK DAGI, Hatice. Tigecycline Therapy in an Infant for Ventriculoperitoneal Shunt Meningitis. Pediatrics, v. 139, n. 1, p. e20160963, 2016. Available at: <https://pubmed.ncbi.nlm.nih.gov/27974589/>. Accessed on: 6 Aug. 2021.
LI, Xingang; SUN, Shusen; WANG, Qiang; et al. Population Pharmacokinetics of Combined Intravenous and Local Intrathecal Administration of Meropenem in Aneurysm Patients with Suspected Intracranial Infections After Craniotomy. European Journal of Drug Metabolism and Pharmacokinetics, v. 43, n. 1, p. 45– 53, 2017. Available at: <https://pubmed.ncbi.nlm.nih.gov/28616823/>. Accessed on: 6 Aug. 2021
GOFMAN, Natalie; TO, Kim; WHITMAN, Marc; et al. Successful treatment of ventriculitis caused by Pseudomonas aeruginosa and carbapenem-resistant Klebsiella pneumoniae with i.v. ceftazidime–avibactam and intrathecal amikacin. American Journal of Health-System Pharmacy, v. 75, n. 13, p. 953–957, 2018. Available at:
<https://pubmed.ncbi.nlm.nih.gov/29941534/>. Accessed on: 6 Aug. 2021.
CHUSRI, Sarunyou; SAKARUNCHAI, Ittichai; KOSITPANTAWONG, Narongdet; et al. Outcomes of adjunctive therapy with intrathecal or intraventricular administration of colistin for post-neurosurgical meningitis and ventriculitis due to carbapenem- resistant acinetobacter baumannii. International Journal ofAntimicrobial Agents, v. 51, n. 4, p. 646–650, 2018. Available at:
<https://pubmed.ncbi.nlm.nih.gov/29241820/>. Accessed on: 6 Aug. 2021.
CEYLAN, Bahadır; ARSLAN, Ferhat; SIPAHI, Oguz Resat; et al. Variables determining mortality in patients with Acinetobacter baumanniimeningitis/ventriculitis treated with intrathecal colistin. Clinical Neurology and Neurosurgery, v. 153, p. 43– 49, 2017. Available at:
<https://www.sciencedirect.com/science/article/abs/pii/S0303846716304322?via%3D ihub>. Accessed on: 6 Aug. 2021.
SHOFTY, B.; NEUBERGER, A.; NAFFAA, M.E.; et al. Intrathecal or intraventricular therapy for post-neurosurgical Gram-negative meningitis: matched cohort study. Clinical Microbiology and Infection, v. 22, n. 1, p. 66–70, 2016. Available at :
<https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(15)00880-0/ fulltext>. Accessed on: 6 Aug. 2021.
ZIAI, Wendy C ; LEWIN, John J. Improving the role of intraventricular antimicrobial agents in the management of meningitis. Current Opinion in Neurology, v. 22, n. 3, p. 277–282, 2009. Available at:
<https://pubmed.ncbi.nlm.nih.gov/19434796/>. Accessed on: 3 Aug. 2021.
NAU, Roland; SEELE, Jana; DJUKIC, Marija; et al. Pharmacokinetics and pharmacodynamics of antibiotics in central nervous system infections. Current Opinion in Infectious Diseases, v. 31, n. 1, p. 57–68, 2018. Available at:
<https://pubmed.ncbi.nlm.nih.gov/29293475/>. Accessed on: 3 Aug. 2021.
Microanatomy Relevant to Intrathecal Drug Delivery. Drug Delivery Systems, p. 109–120, 2019. Available at: <https://pubmed.ncbi.nlm.nih.gov/31435917/>. Accessed on: 3 Aug. 2021.
VAN DE BEEK, Diederik; BROUWER, Matthijs C; THWAITES, Guy E; et al. Advances in treatment of bacterial meningitis. The Lancet, v. 380, n. 9854, p. 1693– 1702, 2012. Available at:
<https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)61186-6/fulltex t>. Accessed on: 22 Aug. 2022
Downloads
Published
How to Cite
License
Os direitos autorais para artigos publicados no Jornal Memorial da Medicina são do autor, com direitos de primeira publicação para a revista. Em virtude de aparecerem nesta revista de acesso público, os artigos são de uso gratuito, com atribuições próprias, em aplicações educacionais e não comerciais. O Jornal Memorial da Medcina permitirá o uso dos trabalhos publicados para fins não comerciais, incluindo direito de enviar o trabalho para bases de dados de acesso público. Os artigos publicados são de total e exclusiva responsabilidade dos autores. Há encargos para submissão no processamento de artigos (Articles Processing Charge - APC).
