Use of capsaicin as a model in the study of migraine: a literature review: Use of capsaicin as a model in the study of migraine: a literature review

Raisa Ferreira Costa; Emanuela Paz Rosas; Daniela Araújo de Oliveira; Marcelo Moraes Valença

doi:10.37085/jmmv3.n1.2021.pp.1-5

Authors

Raisa Ferreira Costa Universidade Federal de Pernambuco https://orcid.org/0000-0002-1180-6689
Emanuela Paz Rosas Universidade Federal de Pernambuco https://orcid.org/0000-0001-9895-5654
Daniela Araújo de Oliveira Universidade Federal de Pernambuco https://orcid.org/0000-0002-6013-978X
Marcelo Moraes Valença Universidade Federal de Pernambuco https://orcid.org/0000-0003-0678-3782

DOI:

https://doi.org/10.37085/jmmv3.n1.2021.pp.1-5

Keywords:

Migraine, Capsaicin, Pathophysiology

Abstract

Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology
of a migraine attack. The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells. A survey was carried out in the literature, from 1980 to 2019, in different databases, using the following terms: capsaicin, mast cell and dura mater. 36 articles were selected for this review. Studies indicate that the main mechanisms of action of capsaicin are chemical induction through the activation of TRPV1 channels,
allowing calcium influx into neurons in the trigeminal ganglion of the dura mater, activating mast cell degranulation, releasing pro-inflammatory (e.g., histamine, oxide nitric) and vasoactive (e.g., CGRP and substance P) substances. Therefore, the use of capsaicin may be a tool to be used in an animal model to better understand the pathophysiology of migraine.

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Author Biography

Emanuela Paz Rosas, Universidade Federal de Pernambuco

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Use of capsaicin as a model in the study of migraine: a literature review